Friday, May 1, 2009

PER:PER Protein Pair Required For Circadian Clock Function

Scientists from Queen Mary, University of London have discovered a new protein complex operating in fruit fly circadian clocks, which may also help to regulate our own biological clocks. Circadian clocks are thought to have evolved to enable organisms to match their behaviour to specific time slots during the 24 hour day. They are synchronised with our surrounding environment via natural light or temperature cycles. Continue reading ...

After about seven months growing in the womb, a human fetus spends most of its time asleep. Its brain cycles back and forth between the frenzied activity of rapid eye movement (REM) sleep and the quiet resting state of non-REM sleep. But whether the brains of younger, immature fetuses cycle with sleep or are simply inactive has remained a mystery, until now. Continue reading ...

A study in the April 15 issue of the Journal of Clinical Sleep Medicine suggests that sleep problems lead to increased pain and fatigue in cancer patients. The results indicate that interventions aimed at trouble sleeping would be expected to improve both pain and fatigue in this patient population. Results show that more than half the sample reported having trouble sleeping, with 26 percent reporting moderate or severe trouble sleeping. Continue reading ...

Cognitive Behavioral Therapy for Insomnia (CBT-I) is an effective treatment for most cases of primary insomnia, and for selected cases of secondary insomnia. There are a variety of behavioral and psychological treatments that comprise CBT-I, including stimulus control therapy, relaxation training, biofeedback, paradoxical intention, sleep restriction therapy, sleep hygiene education, and cognitive therapy. Usually several of these treatments are... Continue reading ...

In an Early Edition issue of The Proceedings of the National Academy of Sciences (PNAS) on April 9, 2009, the researchers report that they have been able to determine the molecular structure of a plant photolyase protein that is surprisingly similar to two cryptochrome proteins that control the "master clock" in humans and other mammals. They have also been able to test how structural changes affect the function of these proteins. Continue reading ...

If you've ever been sleep-deprived, you know the feeling that your brain is full of wool. Now, a study published in the April 3 edition of the journal Science has molecular and structural evidence of that woolly feeling - proteins that build up in the brains of sleep-deprived fruit flies and drop to lower levels in the brains of the well-rested. The proteins are located in the synapses, those specialized parts of neurons that allow brain cells to communicate with other neurons. Continue reading ...

Insomnia is defined as difficulty falling or staying asleep, or the complaint of unrestorative/unrefreshing sleep. Most people experience short-term insomnia from time to time, but when insomnia lasts for more than several weeks, it is considered chronic and should be evaluated by a physician. Insomnia used to be classified by sleep specialists as either primary or secondary insomnia. Secondary insomnia was insomnia that was due to an... Continue reading ...